In aortic stenosis, the major valve through which oxygenated blood leaves the heart narrows. The severity of a patient’s condition, however, does not correlate to their symptom load. Aortic stenosis is treated via an invasive valve-replacement procedure. As such, clinicians often debate whether operations are the right decision for asymptomatic patients. Evidence from Kang et al’s (New England Journal of Medicine 382, 111–119 (2020) recent trial asserts that early interventions significantly lower the risk of cardiovascular mortality among asymptomatic patients.

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